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$998,888

  • For Sale
  • Active
  • Single Family
  • 3 Beds
  • 4 Full Baths
  • 1,630 Sq. Ft.
  • 2 Car Garage
  • Updated 13 days ago
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Ideally located near Downtown South San Francisco and the cities thriving biotech and life-sciences corridor, 643 Grand Avenue where space, comfort, and a remarkable garden setting come together in the heart of South San Francisco. 643 Grand Avenue offers a spacious and versatile layout with excellent access to major transportation and employment centers. The home features 3 bedrooms and 4 bathrooms, with a private full bathroom for each bedroom. Additional highlights include high ceilings, abundant natural light, hardwood floors, a full basement with ample storage, and a detached 2-car garage equipped with a 220-volt outlet for EV charging and an additional 2 car off street parking in front of the house. The home also features a water purification system, tankless water heater, and water softener. The quaint lot includes a freshly manicured organic vegetable garden with sunflowers and offers potential for an ADU. Conveniently located near Downtown South San Francisco, Genentech, Caltrain, US-101, and I-280.

Full Property Details for 643 Grand Ave

General

  • Price: $998,888
  • Status: Active
  • Type: Single Family
  • Source: RE_Infolink
  • MLS ID: ML82059314
  • Updated: 9/29/2026
  • Added to Site: 46 day(s) ago

Interior

  • Interior Features: Skylight, Walk-In Closet
  • Flooring: Hardwood

Rooms

Bathrooms

  • Total Bathrooms: 4
  • Full Bathrooms: 4
  • Bathroom Features: Full on Ground Floor

Bedrooms

  • Total Bedrooms: 3
  • Bedroom Features: Primary Bedroom on Ground Floor

Other Rooms

  • Family Room: No Family Room
  • Kitchen: Dishwasher, Garbage Disposal, Refrigerator
  • Laundry: Washer / Dryer

Additional Information

  • Extras: Not Applicable

Parking

  • Garage Spaces: 2
  • Parking Features: Detached Garage, On Street

Location

  • Area: Old South SF / Rocca
  • County: San Mateo
  • Cross Streets: Orange Avenue

Heating & Cooling

  • Cooling Type: None
  • Heating Type: Central Air (Forced Air)

Utilities

  • Sewer: Public Sewer
  • Water: Public, Water Softener (Owned)
  • Utility Description: Public Utilities

Structural Information

  • Construction: Detached
  • Foundation: Concrete Slab
  • Roof: Shingle
  • Square Feet: 1,630
  • Year Built: 1895

Lot Features

  • Minimum Lot Size: 3500
  • Lot Size (Sq. Ft.): 3,500
  • Zoning: RM0000

Listed by Christie's International Real Estate Sereno, Jill Penna

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Listing agent

— 643 Grand Ave —

  • Jill Penna

    Christie's International Real Estate Sereno

Get Pre-Approved Today

Be ready to buy your new home!

with our affiliated lender
NMLS#: 1598647

Get Pre-Approved

Be ready to buy your new home!

with our affiliated lender
NMLS#: 1598647

Get Pre-Approved

Schools serving 643 Grand Ave

School District:South San Francisco Unified School District
NameGradesDistance
Spruce Elementary School
501 Spruce Avenue, South San Francisco, CA 94080
K-50.3 mi
Parkway Heights Middle School
650 Sunset Avenue, South San Francisco, CA 94080
6-80.6 mi
South San Francisco High School
400 B Street, South San Francisco, CA 94080
9-120.8 mi
Disclaimer: School attendance boundaries provided by ATTOM Data Solutions and are for reference only. Contact the school directly to verify enrollment eligibility.

Price & Sales History for 643 Grand Ave Get Price Alerts and Save Property

Date
Details
Price
Change
Source
9/29/2026
Price Reduced
$998,888
-19.96%
MLS
8/28/2026
Listed
$1,248,000
-4.66%
MLS
11/18/2022
Sold
$1,309,000
—
Public Record
Get Price Alerts and Save Property
Disclaimer: Historical sales information is derived from public records provided by the county offices. Information is not guaranteed and should be independently verified.

Tax History for 643 Grand Ave

Year
Property Taxes
Change
Tax Assessment
Change
2025
$15,489
—
$1,389,000
2%
2025
$15,489
1%
$1,361,766
2%
2024
$15,385
1%
$1,335,065
2%
2023
$15,167
105%
$1,308,888
106%
2022
$7,401
1%
$634,212
2%
2021
$7,304
1%
$621,778
1%
2020
$7,212
1%
$615,404
2%
2019
$7,135
2%
$603,338
2%
2018
$6,965
3%
$591,508
2%
2017
$6,783
2%
$579,910
2%
2016
$6,637
2%
$568,540
2%
2015
$6,529
483%
$560,000
883%
2014
$1,120
—
$56,967
—
2013
$1,122
—
$56,710
—
View All
Disclaimer: Historical tax information is derived from public records provided by the county offices. Information is not guaranteed and should be independently verified.

Estimate the Cost for 643 Grand Ave

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*These costs are estimates, and the interest rates assume exceptional credit standing.

Be ready to buy your new home!

with our affiliated lender
NMLS#: 1598647

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Listed by Christie's International Real Estate Sereno, Jill Penna

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643 Grand Ave, South San Francisco, CA 94080 (MLS# ML82059314) is a Single Family property with 3 bedrooms and 4 full bathrooms. 643 Grand Ave is currently listed for $998,888 and was received on August 28, 2026. Want to learn more about 643 Grand Ave? Do you have questions about finding other Single Family real estate for sale in South San Francisco? You can browse all South San Francisco real estate or contact a Coldwell Banker agent to request more information.

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